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KMID : 0644120120250030071
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Journal of Oriental Gynecology
2012 Volume.25 No. 3 p.71 ~ p.84
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Effects of Pueraria lobata on Body Weight and Gene Expression in Obese Rats Muscle with Estrogen Deficiency
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Shin Hee-Jong
Yoo Jeong-Eun
Jung Eun-Hye
Yoo Dong-Youl
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Abstract
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Objectives: GG is the EtOH fraction of extract of Pueraria lobata. In this study, we aimed to elucidate a possibility that GG reduce obesity and obesity-derived complications such as cardiovascular and metabolic disease.
Methods: The effects of GG on the estrogen-deficient obese rats and the level of gene expression in muscle of rats were investigated.
Results: GG decreased body weight in obese rats with estrogen deficiency. GG increased leptin gene expression in obese rats with estrogen deficiency. GG decreased TNFa gene expression in obese rats with estrogen deficiency. And GG increased PPAR-gamma, PGC-1a, Prdx6, FDFT1, and ACC gene expression of those in obese rats.
Conclusions: We conclude GG might reduce body weight and regulate gene expression of muscle in obese rats.
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KEYWORD
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Pueraria lobata, Gene expression of muscle, Obesity
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